阿魏酸脱羧酶的突变 1,3-丁二烯的合成 Direct 1,3-butadiene biosynthesis in Escherichia coli.pdf

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ARTICLE /10.1038/s41467-021-22504-6 OPEN Direct 1,3-butadiene biosynthesis in Escherichia coli via a tailored ferulic acid decarboxylase mutant 1 1 1 ✉ 1,2,3 Yutaro Mori , Shuhei Noda , Tomokazu Shirai & Akihiko Kondo The C4 unsaturated compound 1,3-butadiene is an important monomer in synthetic rubber

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) and engineering plastic production. However, microorganisms cannot directly produce 1,3-

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7 butadiene when glucose is used as a renewable carbon source via biological processes. In this

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2 study, we construct an artificial metabolic pathway for 1,3-butadiene production from glucose

1 in Escherichia coli by combining the cis,cis-muconic acid (ccMA)-producing pathway together with tailored ferulic acid decarboxylase mutations. The rational design of the substrate- bind

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