肿瘤表观遗传学.pptx
- 118zhuanqian个人认证 |
- 2020-02-20 发布|
- 8.04 MB|
- 97页
Epigenetics in cancer;肿 瘤;世界癌症现状;;What causes cancer?;Carcinogenesis. Some factors to consider…;Heredity ;抑癌基因p53;;Exposure to carcinogens, failure of DNA repair, and progressive genetic
instability lead to accumulation of mutations that drive cancer development,
growth, and metastases. Subclones with new mutations may become dominant
within metastases or within persistent or recurrent cancer deposits
through selective pressures exerted by cytotoxic or targeted chemotherapies.;Cancer Epigenetics;What is Epigentics ?;遗传学 genetics; 基因组印迹
源自双亲的两个等位基因中一个不表达或表达很???。
不遵循孟德尔定律;同卵双胞胎;表观遗传;Why Your DNA Isn’t Your Destiny?;表观遗传学(Epigenetics)
基因的DNA序列不发生改变的情况下，基因的表达水平与功能发生改变，并产生可遗传的表型;遗传与表观遗传;表观遗传学的特点：
可遗传的，即这类改变通过有丝分裂或减数分裂，能在细胞或个体世代间遗传；
可逆性的基因表达调节，也有较少的学者描述为基因活性或功能的改变；
没有DNA序列的改变或不能用DNA序列变化来解释。;拉马克;