0922研究生抗体和细胞因子.pptx

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Antibody and Cytokines

抗体和细胞因子;ANTIBODY and Immunoglobulin;The structure and Function of Immunoglobulin (antibody)

Ig genes and synthesis of protein

Diversity of Ig and its mechanism

Application of antibody;Introduction;introduction;Introduction;Rodney Porter 1917-1985

Nobel Prize in 1972;Ig;Ig;

1)Heavy Chain and Light Chain heavy chain (H chain) 50~75Kd 450~550aa H chain: μ γ α ε δ ;1)Heavy Chain and Light Chain light chain (L chain) 25Kd 214aa classes of L chain: ? ? ?: ?1~ ? 4;2.variable region and constant region variable region(V region) Light Chain - VL (110 aa) Heavy Chain - VH (110 aa) HVR or CDR FR ;HVR or CDR

HVR: hypervariable regions

CDR: the complementarity determining regions.

CDR are found in both the H and the L chains.;structure ;Framework regions

FR (framework region)

reg

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