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Introduction of metabonomics/metabolomics 2009-06-26 第一页，共25页。 The flow of the “omics” sciences: genomics, proteomics, and metabolomics Spratlin J.L. , et al. Clin Cancer Res, 2009 January 15, 15(2):431-440 第二页，共25页。 What’s in a name? Metabolome “… refers to the complete set of small-molecule metabolites (such as metabolic intermediates, hormones and other signalling molecules, and secondary metabolites) to be found within a biological sample, such as a single organism …” Oliver et al., 1998 代谢组“是指基因组的所有下游产物也即最终产物的组合，这些产物是一些参与生物新陈代谢、维持生物体正常功能和生长发育的小分子(fēnzǐ)化合物，主要是相对分子(fēnzǐ)量小于1000Da的内源性小分子(fēnzǐ)” 许国旺著. 代谢组学-方法(fāngfǎ)与应用, 科学出版社，2008年第一版:第一章,P1-10 第三页，共25页。 Metabonomics “…measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or gene