文档介绍
RESEARCH ARTICLE Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish ¨ 1,2† 2† ˆ 2† Mounir El Maı , Marta Marzullo , Ines Pimenta de Castro , Miguel Godinho Ferreira1,2* 1Institute for Research on Cancer and Aging of Nice (IRCAN), Universite´ Coˆ te d’Azur, Nice, France; 2 Instituto Gulbenkian de Cieˆ ncia, Oeiras, Portugal Abstract Progressive telomere shortening during lifespan is associated with restriction of cell proliferation, genome instability and aging. Apoptosis and senescence are the two major outcomes upon irreversible cellular damage. Here, we show a transition of these two cell fates during aging of telomerase deficient zebrafish. In young telomerase mutants, proliferative tissues exhibit DNA damage and p53-de