案例教案生化下课件chapter19.pdf

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Chapter19The tricarboxylicacidcycle1.What Is the Chemical Logic of the TCA Cycle?2.Howis pyruvateoxidativelydecarboxylatedto acetyl‐CoA?3.HowaretwoCO2moleculesproducedfrom acetyl‐CoA?4.Howis oxaloacetateregeneratedto completetheTCAcycle?5.What aretheenergeticconsequencesoftheTCAcycle?6.CantheTCAcycleprovideintermediatesforbiosynthesis?7.What aretheanaplerotic,or “fillingup”,reactions?8.Howis theTCAcycleregulated?9.Canany organismsuseacetate as their solecarbonsource?TricarboxylicacidcycleTCAcycleCitricacidcycleKrebsCycle··KrebscycleA2C+NADFAD+NADHFADHNADHFADHNADFAD22ATPTricarboxylicacidcycle(TCAcycle):Underaerobicconditions,pyruvatefromglycolysisisconvertedtoacetyl-coenzymeA(acetyl-CoA);thenbytheTCAcycleacetyl-CoAisoxidizedtoCOandtheenergyisstoredinNADHandFADH.22acetyl-CoAACoAacetyl-CoATCA

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