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Chapter 11

Genome-Wide Variation

Genome-Wide Variation and Trait Analysis and Trait Analysis Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 11-1 Outline of Chapter 11 Outline of Chapter 11

 Five classes of DNA variation serves as the

 Five classes of DNA variation serves as the basis for direct detection of genotype basis for direct detection of genotype

 Detection of DNA polymorphisms by

 Detection of DNA polymorphisms by hybridization, gel electrophoresis, PCR, hybridization, gel electrophoresis, PCR, microarrays, and sequencing microarrays, and sequencing

 Positional cloning of genes

 Positional cloning of genes Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display 11-2 Extension to Mendelian inition of

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