文档介绍
ImmunomodulatoryeffectofswineCCL20chemokineinDNAvaccinationagainstCSFV;1.Abstract;Remarkably,immunizedanimalswithE2DNAvaccineinco-administrationwiththeplasmidcontainingswineCCL20developedhightitersofneutralizingantibodiesagainsthomologousandheterologous（同源和异源）CSFVstrainsandweretotallyprotecteduponalethalviralchallenge(sterilizingprotection).;2.Introduction;Classicalswinefevervirusisthecausativeagent（病原体）ofclassicalswinefever(CSF),oneofthemostimportantswineinfectiousdiseases.CSFVisanicosahedral(二十面的)RNAviruswith(+)polarity（正极）andalipidenvelope（脂质包膜）thatbelongstothePestivirusGenus（瘟病毒属）oftheFlaviviridaefamily（黄病毒科）.;3.Materialsandmethods;;4.Results;Fig.2.Kineticsofspeci?cCSFVIFNgamma-producingcellsinducedafterimmunizationandCSFVchallenge.OpenbarsindicatepigsinjectedwithpE2andpCDNA3.1+(pigs1–